Distinguishing between toxic and non-toxic pyrrolizidine alkaloids and quantification by liquid chromatography–mass spectrometry

Non-toxic pyrrolizidine alkaloids from Eupatorium semialatum.

The leaves of Eupatorium semialatum were investigated for the occurrence of pyrrolizidine alkaloids. Although this type of alkaloids generally occurs in the Eupatorieae, only unusual non-toxic pyrrolizidines of the tussilagin type were identified. All compounds are methyl esters of the corresponding beta-amino acids.

Toxic Behaviour of Naturally Occurring Pyrrolizidine Alkaloids

The Pyrrolizidine Alkaloids (PAs) are the chemicals which are found in various plant species throughout the world. Pyrrolizidine alkaloids (PAs) are secondary metabolites those have been evolved as a powerful means in the plant defensive system against herbivores. Several studies are being performing to detect presence of PAs in the food and feed which are obtained from plants through direct or...

Identification of Toxic Pyrrolizidine Alkaloids and Their Common Hepatotoxicity Mechanism.

Pyrrolizidine Alkaloids (PAs) are currently one of the most important botanical hepatotoxic ingredients. Glutathion (GSH) metabolism is the most reported pathway involved in hepatotoxicity mechanism of PAs. We speculate that, for different PAs, there should be a common mechanism underlying their hepatotoxicity in GSH metabolism. Computational methods were adopted to test our hypothesis in consi...

Public statement on the use of herbal medicinal products containing toxic, unsaturated pyrrolizidine alkaloids (PAs)

Toxic Amines and Alkaloids from Acacia Rigidula

Acacia ri`idula Benth[\ blackbrush\ is a shrub found growing on rocky ridges in west and southwest Texas and northern Mexico[ Consumption of blackbrush and a related species guajillo\ Acacia berlandieri Benth[\ has been associated with a locomotor ataxia known as {{limber leg||[ In an e}ort to identify the mechanism of this toxicity\ blackbrush was subjected to rigorous chemical analysis[ In ad...